The Lauberth Lab research program is focused on the discovery of clinically distinct alterations in the cancer cell transcriptome and epigenome and how these changes impact patient response and resistance to cancer therapies. We utilize a combination of approaches that include cutting-edge high-throughput NGS technologies, state of the art microscopy techniques, quantitative proteomics, biochemistry, and cell-based/genetic assays. We also employ powerful cell-free assays (consisting of >97 polypeptides) that fully reconstitute transcription on chromatin templates and are powerful in discerning direct (causal) effects of epigenetic and transcriptional regulatory mechanisms. More recently, we have established patient-derived colorectal tumor organoids (PDTO) co-cultured with immune cells to investigate how the crosstalk between mutp53-expressing tumor cells and immune cells contribute to metastatic phenotypes.
Pioneering the function of eRNA's
We are a tight knit group of inquisitive
researchers asking difficult questions to make important advances and discoveries about the mechanisms that drive the epigenome.
We are accepting applications for highly motivated and talented undergraduate/graduate students and postdoctoral fellows. Individuals with a strong background in biology and a record of scientific productivity are encouraged to apply by emailing (email@example.com) me. Please be specific about your research interests in your email.