The Lauberth Lab
The primary focus of our research is to elucidate mechanisms by which tumor promoting GOF p53 mutants deregulate gene expression, resulting in more than 50% of all human cancers. To address this research goal, we use human cancer cell models, mouse models, and human tumors to investigate independent and combined functions of various GOF p53 mutants, transcriptional coregulators, and epigenetic modifiers in regulating gene expression during key transitions that occur in cancer cells following exposure to stimuli from the tumor microenvironment. We also implement unique cell free assays that together with designer chromatin templates drill down into the biochemical basis of the underlying mechanisms that shape mutant p53-dependent gene expression programs.
Our research studies will ultimately advance the potential for target based screening approaches, an issue of great significance in light of the recent successes in targeting histone modification effector proteins/readers for developing cancer therapies.
We are accepting applications for highly motivated and talented undergraduate/graduate students and postdoctoral fellows. Individuals with a strong background in biology and a record of scientific productivity are encouraged to apply by emailing (email@example.com) me. Please be specific about your research interests in your email.