In the last few years, our lab’s research has advanced our understanding of how enhancer landscapes and epigenetic mechanisms shape the expression profiles of cancer-associated gene networks that are linked to enhanced tumor development and metastatic progression.  

Our research has revealed a new mechanism in which mutp53 together with the histone monomethyltransferase MLL4 gives rise to alterations in the deposition of histone H3 lysine 4 monomethylation (H3K4me1), which is a histone modification that is frequently altered in various human cancers. We also revealed that these changes in the chromatin environment promote cancer cell migration and invasion through the potent activation of a subset of mutp53 target genes.

Characterized a new role for the basal transcription factor TFIID complex in cellular signaling during muscle development

1. Revealed a new regulatory mechanism to describe how chronic immune signaling fuels cancer cell growth

2. Identified new mechanistic insights into how epigenetic modifications in cancer are established

3. Are at the forefront of uncovering new
mechanistic insights into the functions of a class of significantly understudied
noncoding molecules referred to as enhancer RNAs (eRNAs)

©2018 by Lauberth Lab.